Actonel disasterous side effects-jaw osteonecrosis (ONJ) is a defacement in which part of the jaw bone is no longer alive and cannot resurrect itself due to a lack of blood supply.Ordinarily in the past, patients developed ONJ after bone damage, such as a tooth extraction. Rather than healing, the bone begins to die. In some instances, the bone becomes exposed, which can lead to dangerous infection and fracture. In extreme instances, surgery is required to remove the dead bone.
The most frequent indications and symptoms of ONJ include pain, soft-tissue and jaw swelling, loosening of teeth, drainage, exposed bone, and infection. Numbness, heaviness and other feelings in the jaw may also be in existence in some individuals. In order to diagnose ONJ, doctors may perform panoramic and tomographic imaging. They may also take microbial cultures and tissue biopsies in order to rule out other kinds of infections. Early unearthing of ONJ is crucial to keeping the jawbone.
Between 2001 and 2003, two oral surgeons, Salvatore Ruggiero and Robert Marx, specialists in problems of the jaw, began researching ONJ after seeing an uncommon multiply in the number of patients with deteriorating jawbones.After meticulously analysing the medical records and histories of their patients, the two surgeons came across that only one common thread existed– the patients had been treated with Aredia or Zometa.
Aredia and Zometa are intravenous bisphosphonates. Bisphosphonates are a class of bone-strengthening drugs used to mitigate bone loss related with multiple myeloma, bone metastases in patients with advanced cancers, and osteoporosis. Practically all of patients seen by Dr. Ruggiero and Dr. Marx were cancer victims.
Bisphosphonates stave off metastatic cancer cells from dissolving bone. However, new cells will not grow unless older old ones areobliterated. Bisphosphonates bond to bone surfaces and arrest osteoclasts (cells that breakdown bone) from doing their job. Because jawbones have rapid cell turnover, bisphosphonates can affect their powers to regrow. The by-product is that the jawbone does not heal properly after any serious jolt, i.e., dental treatment, and patients are vulnerable to infections and ONJ.
By September 2003, both Dr. Ruggiero and Dr. Marx had made known articles regarding the affiliation between ONJ and bisphosphonates. In September 2004, Novartis and the FDA revised the labels of Aredia and Zometa to include a precautionary statement about the potential risk of getting ONJ. Novartis also circulated letters to physicians warning them of this potential awful side effect.
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FOSAMAX , AREDIA , ZOMETA and ACTONEL usage has been linked to the catastrophic condition “Dead Jaw” (ONJ - Osteonecrosis of the Jaw).
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