Osteogenesis Imperfecta

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    Osteogenesis Imperfecta

Urgent medical-dental alert for people who took      
FOSAMAX ®, AREDIA ® or ZOMETA ®

These drugs have been linked to the catastrophic condition(s)
 “DEAD JAW” (Osteonecrosis of the jaw)
& other severe jaw cancer conditions

If you or a loved one has been taking any of these “Bisphosphonates” for
Osteogenesis Imperfecta ,Osteonecrosis of the jaw,Osteoporosis,
Cancer or Multiple Myeloma, Avascular Necrosis
& you have experienced jaw or other complications, you must act now!

    YOU MAY DESERVE COMPENSATION!
for osteogenesis imperfecta of the jaw drug side effects

 Contact today the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly
or email us at

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212

 

 

 

Osteogenesis Imperfecta Drug Side Effects Article Links
Osteogenesis Imperfecta of the jaw Side Effects linked to jawbone death
 .or bone tumors. But about 10% were osteoporosis patients who had taken an oral bisphosphonate, mainly Fosamax and Zometa. In May, Ruggiero ..Osteogenesis imperfecta of the jaw.
 Osteogenesis Imperfecta of the jaw side effects causes Jaw Problems 
...given bisphosphonates intravenously. Some patients take oral bisphosphonates, such as Fosamax and Zometa, for osteoporosis. The FDA acknowledges .Osteonecrosis of the jaw..
Jaw Cancer Side Effects Linked to Jaw Osteoporisis
 ..or Zoledronate/Zoledronic Acid ( Zometa ) therapy for malignancy, but several have occurred after oral treatment with Alendronate ( Fosamax, Zometa ) or Risedronate .osteogenesis imperfecta.. - Xagena.it
Osteogenesis imperfecta of the jaw Cancer Lawsuit Blog
Jaw Osteogenesis imperfecta Cancer Side Effect Information
Osteonecrosis of the jaw osteogenesis imperfecta Cancer Compensation for Osteogenesis imperfecta of the jaw Cancer Side Effects
Zometa and Fosamax Jaw osteogenesis imperfecta Cancer Information/ 
Jaw Cancer ONJ Side Effects Blogs/
More Osteonecrosis of the jaw Drug Side Effects Blogs
Lawyer for Osteonecrosis of the jaw Side Effects
Lawyer for Avascular Necrosis Jaw cancer Conditions
Osteogenesis imperfecta of the jaw Litigation
Zometa and Osteonecrosis of the jaw lawsuit
Zometa and Jaw Disease Lawsuit
Jaw Disease  and Zometa
Symptom osteogenesis imperfecta of the jaw
Osteonecrosis of the jaw Fosamax  Lawsuit Cancer Class Action
Jaw Cancer Danger
Symptom of Osteonecrosis of the jaw
Cancer in Jaw for Osteopenia
Avascular Necrosis Jaw Information
Bone Cancer Jaw Symptom lawsuit
Bone Cancer Jaw Avascular Necrosis symptom lawyer
Jaw Cancer Litigation
Jaw Cancer Osteoporosis
Jaw Cancer Side Effect
Jaw Cancer Side Effects
Jaw Cancer Warning

Questions and Answers About Osteogenesis Imperfecta

 Osteogenesis Imperfecta

What is osteogenesis imperfecta?
Osteogenesis imperfecta (OI), also known as brittle-bone disease, is a genetic (inherited) disorder characterized by bones that break easily without a specific cause. An estimated 20,000 to 50,000 people in the US have this disease.

The disorder occurs in one out of 20,000 to one out of 60,000 live births. OI can affect males and females of all races.

What causes osteogenesis imperfecta?
The cause of OI is believed to be due to a genetic defect that causes imperfectly-formed, or an inadequate amount of, bone collagen - a protein found in the connective tissue.

What are the types and symptoms of OI?
The following are the most common symptoms for osteogenesis imperfecta. However, each individual may experience symptoms differently. Although symptoms may vary, generally they are used to classify the four forms of OI, each of which represents the severity of the condition.

According to the Osteoporosis and Related Bone Diseases National Resource Center, part of the National Institutes of Health (NIH), the types of OI and their symptoms include the following:

Type I:
  • most common
  • bones fracture easily
  • can usually be traced through the family
  • near normal stature or slightly shorter
  • blue sclera (the normally white area of the eye ball)
  • dental problems
  • hearing loss beginning in the early 20s and 30s
  • most fractures occur before puberty; occasionally women will have fractures after menopause
  • triangular face
  • tendency toward spinal curvatures
Type II:
  • newborns severely affected; frequently fatal
  • usually resulting from a new gene mutation
  • very small stature with extremely small chest and under developed lungs
Type III:
  • tend to be isolated family incidents
  • very small in stature - some only 3 feet tall
  • fractures at birth very common
  • x-ray may reveal healing of in utero fractures
  • severe early hearing loss
  • loose joints and poor muscle development in arms and legs
  • barrel-shaped rib cage
Type IV:
  • can frequently be traced through the family
  • bones fracture easily - most before puberty
  • normal or near normal colored sclera
  • problems with teeth - more than Type I
  • spinal curvatures
  • loose joints

The symptoms of osteogenesis imperfecta may resemble other medical conditions or problems. Always consult your physician for a diagnosis.

How is osteogenesis imperfecta diagnosed?
In addition to a complete medical history and physical examination, diagnostic procedures for osteogenesis imperfecta may include a skin biopsy to evaluate the amount and structure of collagen. However, this test is complicated and not many qualified facilities are available to perform the procedure. It is not unusual for results of the biopsy to take up to six months.

Additional diagnostic tests may include:
  • x-ray - a diagnostic test which uses invisible electromagnetic energy beams to produce images of internal tissues, bones, and organs onto film
  • an examination of the ear, nose, and throat (to detect hearing loss)

Treatment for Osteogenesis Imperfecta
Specific treatment for osteogenesis imperfecta will be determined by your physician based on:

  • your age, overall health, and medical history
  • extent of the disease
  • your tolerance for specific medications, procedures, or therapies
  • expectations for the course of the disease
  • your opinion or preference
To date, there is no known treatment, medicine, or surgery that will cure osteogenesis imperfecta (OI). The goal of treatment is to prevent deformities and fractures and allow the child to function as independently as possible. Treatments for preventing or correcting symptoms may include:
  • care of fractures
  • surgery
  • rodding - a procedure to insert a metal bar the length of a long bone to stabilize it and prevent deformity
  • dental procedures
  • physical therapy
  • assistive devices, such as wheelchairs, braces, and other custom-made equipment
Management of Osteogenesis Imperfecta (OI)
Management of the disease includes focusing on preventing or minimizing deformities, and maximizing the individual's functional ability at home and in the community. Management of OI is either non-surgical or surgical. Non-surgical interventions may include one or more of the following:  
  • physical therapy
  • positioning aids (to help sit, lie, or stand)
  • braces and splints (to prevent deformity and promote support or protection)
  • medications
  • psychological counseling
Surgical interventions may be considered to manage the following conditions:
  • fractures
  • bowing of bone
  • scoliosis - a lateral, or sideways curvature and rotation of the back bones (vertebrae), giving the appearance that the person is leaning to one side.
  • heart problems
Surgery may also be considered to maintain the ability to sit or stand. Long-Term Outlook for an Individual with Osteogenesis Imperfecta (OI)
Osteogenesis imperfecta (OI) is a progressive condition that needs life-long management to prevent deformity and complications. The interdisciplinary healthcare team helps the family to improve the functional outcomes and to provide support. The Osteogenesis Imperfecta Society can also be an important resource.

 

 

 

Osteonecrosis of the Jaw Information

 Fosamax ( generic name - Alendronate ) is a type of drug known as bisphosphonates. Recently a link has been found between bisphosphonates and a serious bone cancer disease called osteonecrosis of the jaw ( ONJ ). This important discovery clearly shows that Fosamax side effects may include osteonecrosis of the jaw.

The discovery, published in the Journal of Oral and Maxillofacial Surgeons, prompted both the US, Food and Drug Administration ( FDA ) and Novartis, the manufacturer of bisphosphonates used in cancer chemotherapy, to issue a warning to health care professionals on September 24, 2004. The warning letter contained information about jaw cancer and bisphosphonates and the risks of osteonecrosis in the jaw.

Bisphosphonates are commonly used in tablet form such as Fosamax ( Alendronate Sodium ) to prevent and treat osteoporosis in post-menopausal women. Stronger forms of bisphosphonates are commonly used in the management of advanced cancers that have metastasized to the bone, where the disease often causes bone pain and possibly even fractures. Several cancers can involve or metastasize to the bone, including lung cancer, breast cancer, prostate cancer, multiple myeloma,jaw cancer, and others. When bisphosphonates are given in cancer chemotherapy, the drugs are given intravenously, and usually for longer periods of time.

If you or a loved one have jaw cancer and have been injured as a result of Fosamax,Zometa, and Aredia side effects such as osteonecrosis of the jaw contact today the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
.
.

Osteonecrosis of the Jaw
Jaw Cancer
Osteonecrosis of the jaw ( ONJ ) is a condition in which the bone tissue in the jaw fails to heal after minor trauma such as a tooth extraction, causing the bone to be exposed. The exposure can eventually lead to infection and fracture and may require long-term antibiotic therapy or surgery to remove the dying bone tissue. Experts say that prevention and early treatment of individuals using bisphosphonates such as Fosamax is extremely important in preserving the jaw bone. Individuals using Fosomax or other bisphosphonates should attempt to avoid tooth extractions and other major dental work while on the drugs.

Although most cases of osteonecrosis of the jaw related to Fosamax side effects have occured after dental work several cases have been reported to occur without any prior dental work. If you are currently taking Fosamax,Zometa, and Aredia you may be at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa, and Aredia side effects you may be entitled to compensation. For more information about your legal rights contact the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212

 

 

Although most cases of osteonecrosis of the jaw related to Fosamax side effects have occured after dental work several cases have been reported to occur without any prior dental work. If you are currently taking Fosamax,Zometa, and Aredia you may be at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa, and Aredia side effects you may be entitled to compensation. For more information about your legal rights contact the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212




Although most cases of osteonecrosis of the jaw related to Fosamax side effects have occured after dental work several cases have been reported to occur without any prior dental work. If you are currently taking Fosamax,Zometa, and Aredia you may be at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa, and Aredia side effects you may be entitled to compensation. For more information about your legal rights contact the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212

 

 

 

 

 

 

 

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 116  osteogenesis imperfecta type 2
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 38  cause of osteogenesis imperfecta
 33  bones brittle disease imperfecta osteogenesis
 33  osteogenesis imperfecta symptom
 32  osteogenesis imperfecta photo
 28  osteogenesis imperfecta and child abuse

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