Breast Cancer Drug Side Effects

Urgent medical-dental alert for people who took      
ZOMETA ®, FOSAMAX ®, or AREDIA ®

These drugs (Zometa, Fosamax, and Aredia)
have been linked to the catastrophic condition(s)
 “DEAD JAW” (Osteonecrosis of the jaw)
& other severe conditions

If you or a loved one has been taking any of these “Bisphosphonates”
for Breast Cancer, Osteoporosis,
Cancer or Multiple Myeloma &
you have experienced complications, you must act now!

    YOU MAY DESERVE COMPENSATION!
for breast cancer drug side effects


Contact today the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212

 Fosamax ( generic name - Alendronate ),Zometa and Aredia are types of drugs known as bisphosphonates. Recently a link has been found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw ( ONJ ). This important discovery clearly shows that Aredia side effects may include osteonecrosis of the jaw.

The discovery, published in the Journal of Oral and Maxillofacial Surgeons, prompted both the US, Food and Drug Administration ( FDA ) and Novartis, the manufacturer of bisphosphonates used in cancer chemotherapy, to issue a warning to health care professionals on September 24, 2004. The warning letter contained information about bisphosphonates and the risks of osteonecrosis in the jaw.

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
.
.

Osteonecrosis of the Jaw
Osteonecrosis of the jaw ( ONJ ) is a condition in which the bone tissue in the jaw fails to heal after minor trauma such as a tooth extraction, causing the bone to be exposed. The exposure can eventually lead to infection and fracture and may require long-term antibiotic therapy or surgery to remove the dying bone tissue. Experts say that prevention and early treatment of individuals using bisphosphonates such as Fosamax or Zometa is extremely important in preserving the jaw bone. Individuals using Fosomax, Zometa or other bisphosphonates should attempt to avoid tooth extractions and other major dental work while on the drugs.

Although most cases of osteonecrosis of the jaw related to Fosamax,Aredia or Zometa side effects have occured after dental work several cases have been reported to occur without any prior dental work. If you are currently taking Fosamax or Zometa you may be at risk of developing osteonecrosis. If you have been injured by Fosamax,Aredia or Zometa side effects you may be entitled to compensation. For more information about your legal rights contact the offices of

Contact today the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212

• What is Breast cancer
  
   Breast cancer is a type of cancer in which cells in the breast become abnormal and grow and divide uncontrollably.

Normal Cells
Normal cells divide, grow, and die on a continual, controlled basis. The nucleus of each cell contains genes made up of DNA that 'tells' that cell what to do and determines its lifespan. When cells grow uncontrollably, they will eventually form a mass, also called a tumor. Benign tumors are not cancer, they do not invade other types of tissue, but they may pose problems depending on their size and location if they grow large enough to interfere with a bodily function (such as blood or urine flow) or put too much pressure on an organ or nerve.

Cancer
Malignant tumors are made up of abnormal cells that are capable of invading nearby tissues.

Cells from the original tumor may also break off and travel via the blood or lymph systems to distant location (metastasize). When these cancer cells grow in another organ, the cancer will still be named for the organ where it began. For example, if breast cancer cells travel to the liver and grow there, that person would have metastisized breast cancer, not liver cancer.

How Cancer Grows
Cancer cells grow and divide at an abnormally rapid rate, so they need extra nutrients. Since cells get their requirements supplied by the blood, malignant tumors build new blood vessels - a process called angiogenesis. Developing treatments to stop this process (called anti-angiogenesis) is one promising area of cancer research.

What Causes the Cells To Grow Uncontrollably?
A change or mutation in the genes of a cell changes the way that cells acts. The mutation may exist at birth from an inherited genetic trait from a mother or father or it may be spontaneous - a change that occurs sometime after birth. Inheriting the BRCA1 or BRCA2 gene has been identified as a factor in raising the risk of developing breast cancer.

When you hear that a substance is carcinogenic, Some substances, such as cigarettes, have been identified as carcinogens, meaning it is capable of causing a spontaneous genetic mutation that can cause a cancer to begin. Most of the causes of cancer, however, remain unknown. Research is ongoing to understand exactly how each each carcingen causes genetic mutation in hopes of then finding a way to block it.

What is an Oncogene?
Researchers have identified two genes that control cell grow and division. One is called an oncogene, which gives the command to grow & divide....think of it as the "on" switch. The other is called a tumor-suppressor gene, which tells the cell to stop growing and dividing (think of this as the "off" switch). If the oncogene doesn't stop giving its "on" command or the tumor suppression gene doesn't give its "off" command, the cell will grow & divide uncontrollably.

Breast Cancer
The majority (over 75%) of breast cancers begin in the (milk) ducts within the breast; the next most common site is the lobules - the glandular tissue that makes milk. Most breast cancers are slow-growing and by the time a lump can be felt, it may have been growing for 5 or 10 years. Early breast cancer usually has no symptoms and the earlier a tumor is found, the better the chance of survival. For these reasons it is extremely important for women to be screened regularly by mammography or ultrasound since they may identify a cancerous tumor before it can be felt. In addition, if a lump or thickening can be felt, it is vital to seek a medical evaluation right away.

 Zometa, Fosamax, and Aredia Breast Cancer Drug Side Effects News Articles

 IMF: Aredia and Zometa and osteonecrosis of the jaws A New Update ...

 ADRAC : bisphosphonates and osteonecrosis of the jaw

ABC News: Novartis(Aredia,Zometa) Sees Jaw Damage in Cancer Drug Patients

... Novartis AG has received 875 reports of jaw problems in patients treated with two cancer drugs, but it ... sign the cases were related to the drugs, Zometa and Aredia. FDA officials urged further study to ...

• abcnews.go.com/Health/wireStory?id=552022
  
  

 http://www.bethesda.med.navy.mil/careers/postgraduate_dental_school/research/clinical_updates/2005/0... (MICROSOFT WORD)

Bisphosphonates Can Wreak Havoc in the Mouth and Jaws, Oral and Maxillofacial Surgeon Warns

... Report | Contact MedWatch Zometa (zoledronic acid) Aredia ... of osteonecrosis of the jaw (ONJ) observed in cancer patients ... disorders. Mislabeling problems with certain lots of this product ...

• www.fda.gov/medwatch/SAFETY/2005/safety05.htm