Brittle Bone Disease Drug Side Effects
Urgent medical-dental alert for people who took
FOSAMAX ®, AREDIA ® or
ZOMETA ®
These drugs have been linked to
the catastrophic side effects
“DEAD JAW” (Osteonecrosis of the jaw)
&
other severe side effects
If you or a loved one has been taking any of these “Bisphosphonates”
for Osteoporosis,
Cancer, Hypercalcemia,
Paget's Disease,
Brittle Bone Disease
or Multiple Myeloma
& you have experienced
side effects,
you must act now!
YOU MAY DESERVE COMPENSATION!
for
Brittle Bone Disease Drug
Side Effects
Contact today the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S. and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
|
Brittle
Bone
Disease Information
Brittle Bone Diseases
(Osteogenesis Imperfecta)
The brittle bone diseases are a large group of conditions characterised by excessive fragility of the bones, present from childhood.
The most common cause of the disorder is osteogenesis imperfecta which is a group of conditions all caused by inherited defects of collagen (the protein responsible for the strength of the bone). The severity of the condition may vary. Some affected individuals have multiple fractures, in others the condition is difficult to diagnose.
It is conventional to describe four varieties of osteogenesis imperfecta. Type II usually causes such severe fractures that infants are stillborn or die in the first few weeks of life. Type III is severe but consistent with good survival although there may be markedly impaired growth. Types I and IV are milder conditions with good stature and relatively few fractures. Type I is characterised by distinctly blue/grey sclerae (whites of the eyes) which is not seen in Type IV. Associated problems may include lax joints, fragile teeth, excessive sweating and easy bruising.
Other less common causes of brittle bone disease include osteopetrosis hypophosphatasia, fibrous dysplasia (Albright Syndrome) and ideopathic juvenile osteoporosis. Additionally temporary brittle bone disease may cause fractures in the first year of life and improve later. This is still not well understood. Fracture in childhod may also be caused by rickets due to vitamin D deficiency.
Synonyms- Brittle Bone Disease
- Ekman-Lobstein Disease
- Lobstein Disease (Type I)
- OI
- Vrolik Disease (Type II)
- Osteogenesis Imperfecta Type I
- Osteogenesis Imperfecta Type II
- Osteogenesis Imperfecta Type III
- Osteogenesis Imperfecta Type IV
Brittle Bone Disease Drug Side Effects Information
Zometa and Fosamax ( generic name - Alendronate ) is a type of drug known as bisphosphonates. Recently a side effect link has been found between bisphosphonates and a serious brittle bone disease called osteonecrosis of the jaw ( ONJ ). This important discovery clearly shows that Zometa side effects may include osteonecrosis of the jaw, a serious side effect.
The discovery, published in the Journal of Oral and Maxillofacial Surgeons, prompted both the US, Food and Drug Administration ( FDA ) and Novartis, the manufacturer of bisphosphonates used in cancer chemotherapy and hypercalcemia, to issue a warning to health care professionals on September 24, 2004. The warning letter contained information about bisphosphonates and the risks of osteonecrosis in the jaw.
Bisphosphonates are commonly used in tablet form such as Zometa and Fosamax ( Alendronate Sodium ) to prevent and treat osteoporosis and brittle bone disease in post-menopausal women and Hypercalcemia Stronger forms of bisphosphonates are commonly used in
the management of advanced cancers that have metastasized to the bone, where
the disease often causes bone pain and possibly even fractures. Several cancers
can involve or metastasize to the bone, including lung cancer, breast cancer,
prostate cancer, multiple myeloma, and others. When bisphosphonates are given
in cancer chemotherapy, the drugs are given intravenously, and usually for
longer periods of time.
If you or a loved one have taken
Zometa and Fosamax for brittle bone disease and have been
injured as a result of Fosamax and Zometa side effects such as osteonecrosis of the jaw
contact today the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S. and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
.
.
Osteonecrosis of the Jaw
Osteonecrosis of the jaw ( ONJ ) is a condition in which the bone tissue in the
jaw fails to heal after minor trauma such as a tooth extraction, causing the
bone to be exposed. The exposure can eventually lead to infection and fracture
and may require long-term antibiotic therapy or surgery to remove the dying
bone tissue. Experts say that prevention and early treatment of individuals
using bisphosphonates such as Fosamax is extremely important in preserving the
jaw bone. Individuals using Fosomax or other bisphosphonates should attempt to
avoid tooth extractions and other major dental work while on the drugs.
Although most cases of osteonecrosis of the jaw related to Fosamax side effects
have occured after dental work several cases have been reported to occur
without any prior dental work. If you are currently taking Fosamax you may be
at risk of developing osteonecrosis. If you have been injured by Fosamax side
effects you may be entitled to compensation. For more information about your
legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S. and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
More Brittle Bone Disease Drug Side Effects Articles
Zometa Jaw Bone Injury Awareness Program Should Be Enhanced ... Mar 9, 2005
Dissemination
of Novartisâ Dear Doctor letters for Zometa and Aredia
concerning osteonecrosis of the jaw side effects risk should be extended to
dentists, members ..brittle bone. - FDA Advisory Committee
Drug linked to death of jawbone
side effects Mar 13, 2005
Most
were cancer patients who had received the intravenous bisphosphonates
Zometa or Aredia or both for excessive calcium in their blood or bone
tumors. ..Pagets. - USA Today
Novartis Sees Jaw Damage in Cancer Drug Patients Mar 4, 2005
A
Food and Drug Administration official said there was a "highly
plausible" sign the cases were related to the drugs, Zometa and Aredia.
.brittle bone disease.. - Reuters
Bisphosphonate Osteonecrosis May Be Class Effect, FDA Safety ... Mar 3, 2005
ODS
conducted a post-marketing safety review of the approved
bisphosphonates Novartis’ Zometa (zoledronic acid) and Aredia
(pamidronate), Merck’s Fosamax ... - FDA Advisory Committee
Cancer drugs stopped mid-treatment Mar 10, 2005
On
February 9, without explanation or informed consent, she was told that
the drug Zometa, which was helping her fight cancer, would be stopped.
..side effects. - Scoop.co.nz (press release),
Questions & Answers for Oral Answer 10 March 2005 Mar 9, 2005
I
am advised by Dr Nigel Murray of the board that the change made for the
treatment Mrs Borich received as part of her cancer treatment, from
Zometa to Aredia ..side effects. - Scoop.co.nz (press release),
Cytogen Corporation Provides QUADRAMET(R) Clinical Development and ... Mar
17, 2005
...at
the University of Maryland in Baltimore evaluating the potential
benefits of combination treatments including QUADRAMET and zoledronic
acid (Zometa(R)) in ... - PR Newswire (press release)
IMS Health annonce une croissance de 7 % de ses ventes mondiales ... Mar 9, 2005
..."Today,
there are seven anti-cancer drugs -- MabThera(R), Glivec(R),
Eloxatine(R), Gemzar(R), Casodex(R), Taxotere(R) and Zometa(R) -- that
have achieved ... - Le Revenu,
ADRAC : bisphosphonates and osteonecrosis of the jaw Mar 9, 2005
Most
of the cases have occurred following intravenous Pamidronate ( Aredia,
Pamisol ) and/or Zoledronate/Zoledronic Acid ( Zometa ) therapy for
malignancy, but ... - Xagena.it,
Drug linked to death of jawbone 14 Mar 2005
Most
were cancer patients who had received the intravenous bisphosphonates
Zometa or Aredia or both for excessive calcium in their blood or bone
tumors. side effects... - USA Today
Zometa Jaw Bone Injury Awareness Program Should Be Enhanced ... Mar 9, 2005
Dissemination
of Novartis’ “Dear Doctor� letters for Zometa and Aredia
concerning osteonecrosis of the jaw risk should be extended to
dentists, members ... - FDA Advisory Committee
Cancer drugs stopped mid-treatment Mar 10, 2005
On
February 9, without explanation or informed consent, she was told that
the drug Zometa, which was helping her fight cancer, would be stopped.
... - Scoop.co.nz (press release),
Patients 'distressed' at switch to cheaper cancer drug Mar 10, 2005
Van't
Hof and the son and daughter of Mrs Borich describing the distress of
the patients at having their chemotherapy changed last month from
Zometa to Aredia ... - New Zealand Herald,
Jaw Osteonecrosis Associated With Bisphosphonates in Some Cancer ... Mar 7, 2005
A
Food and Drug Administration official said there was a "highly
plausible" sign the cases were related to the drugs, Zometa (zoledronic
acid) and Aredia ... - Medscape (subscription) pagets disease
Bisphosphonate Osteonecrosis May Be Class Effect, FDA Safety ... Mar 3, 2005
ODS
conducted a post-marketing safety review of the approved
bisphosphonates Novartis’ Zometa (zoledronic acid) and Aredia
(pamidronate), Merck’s Fosamax ... - FDA Advisory Committee
Questions & Answers for Oral Answer 10 March 2005 Mar 9, 2005
I
am advised by Dr Nigel Murray of the board that the change made for the
treatment Mrs Borich received as part of her cancer treatment, from
Zometa to Aredia ... - Scoop.co.nz (press release),
Postcode lottery over prostate cancer drug Feb 25, 2005
The
drug Zometa, which is used for patients whose cancer has spread to the
bones, has not been approved for use in Scotland, despite being
available in England ... - Scotsman,
Modified Taxotere® Regimen Effective for Advanced Prostate Cancer Feb 25, 2005
Researchers
from Greece have reported that the treatment combination consisting of
Taxotere® (docetaxel), estramustine (Emcyt®) and Zometa® (zoledronic
acid ... - Cancer Consultants (press release),
IMS Health annonce une croissance de 7 % de ses ventes mondiales ... Mar 9, 2005
..."Today,
there are seven anti-cancer drugs -- MabThera(R), Glivec(R),
Eloxatine(R), Gemzar(R), Casodex(R), Taxotere(R) and Zometa(R) -- that
have achieved ... - Le Revenu,
ADRAC : bisphosphonates and osteonecrosis of the jaw Mar 9, 2005
Most
of the cases have occurred following intravenous Pamidronate ( Aredia,
Pamisol ) and/or Zoledronate/Zoledronic Acid ( Zometa ) therapy for
malignancy, but .brittle bone disease.. - Xagena.it,
Amgen's AMG-162 for treatment of osteoporosis will become a ... Feb 23, 2005
..."Much
of the growth will be due to the launch of new bisphosphonates,
including Roche's Boniva/Bonviva (ibandronate), Novartis's Zometa
(zoledronate), and ... - News-Medical.net,
A mission that Feb 18, 2005
Bocala's
care requires daily amounts of pain management, a monthly IV-drip of
Zometa to strengthen her bones, and bone and CAT scans every three
months to ... - OregonLive.com,
Other resources:
Zometa archived articles: Zometa archive
Government Links for Zometa: Zometa resources from the U.S. government
Academic links for Zometa: Zometa academic resources
Zometa Old archives: Zometa archive
Zometa 2003 articles: Zometa archive
Zometa Side Effects Warning - Consumers May Deserve Compensation Apr 26, 2005
...(PRWEB)
April 27, 2005 -- Fosamax Side Effects Warning - Fosamax ( generic name
- Alendronate ) is a type of drug known as bisphosphonates. ... -
Emediawire (press release),
Link found between bisphosphonates(Fosamax, Zometa, and Aredia) and a serious bone disease ...
| ... (LIJ) Medical Center recently discovered a link between a common chemotherapy
drug and a serious bone disease called osteonecrosis of the jaw (ONJ). www.news-medical.net/?id=6844 - 26k - |
Link found between Fosamax and Zometa bisphosphonates and a serious bone disease ...
... drug and a serious bone disease called osteonecrosis of the jaw (ONJ). ... were struck by a cluster of cancer patients with necrotic lesions in the jaw ...
www.news-medical.net/print_article.asp?id=6844 - 13k -Cached - Similar pages
Doctors link biphosphonate drugs(Fosamax,Zometa, and Aredia) for osteoporosis and cancer to ...
| ... drug and a serious bone disease called osteonecrosis of the jaw. ... they were
struck by a cluster of cancer patients with necrotic lesions in the jaw ... psa-rising.com/med/side_effects/osteo-necrosis.htm - 10k - |
Calcium and Vitamin D Fail in Fracture Prevention 29 Apr 2005
These
include agents such as Fosamax (alendronate), Zometa (zoledronate),
Boniva (ibandronate), Aredia (pamidronate), Didronel (etidronate), and
Actonel ... - MedPage Today,
Steroid use: Balancing the risks and benefits Apr 27, 2005
And
taking calcium and vitamin D supplements and prescription
bisphosphonates, such as Zometa,alendronate (Fosamax) or risedronate
(Actonel), can minimize bone ... - MayoClinic.com
What I know in my bones Apr 24, 2005
These
drugs include Fosamax and Actonel. They belong to the antiresorptive
drug class. ... Newer once-a-week forms of Fosamax,Zometa and Actonel help
ease taking them. ... - Vail Daily News,
Planet Cancer Forums - View Topic
| ... growth of bone metastases can develop bone death in the jaw the FDA warns.
... given to cancer patients with metastases to the bone as standard therapy. ... www.planetcancer.org/forum/ viewtopic.php?topic=925&forum=32&4 - 16k - |
HealthBoards - Bisphosphonates & Rheumatoid Arthritis
| ... For instance fosamax is not to be taken with meals, but on an empty ...
It is used primarily to treat bone cancer patients, so you would find it at ... www.healthboards.com/boards/ showthread.php?goto=lastpost&t=210107 - 59k - |
If you are currently taking Zometa you may be at risk of developing osteonecrosis. If you have been injured by Zometa side effects you may be entitled to compensation. For more information about your legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S. and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212