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Osteonecrosis of the jaw Side Effects Article Links
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Osteonecrosis
of the jaw
Side Effects linked to jawbone death
.or
bone tumors. But about 10% were osteoporosis patients who had taken an
oral bisphosphonate, mainly Fosamax and Zometa. In May, Ruggiero ..Osteonecrosis
of the jaw.
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Osteonecrosis
of the jaw
side effects causes Jaw Problems
...given
bisphosphonates intravenously. Some patients take oral bisphosphonates,
such as Fosamax and Zometa, for osteoporosis. The FDA acknowledges .Osteonecrosis
of the jaw..
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Jaw
Cancer
Side
Effects
Linked to Jaw Osteoporisis
..or
Zoledronate/Zoledronic Acid ( Zometa ) therapy for malignancy, but
several have occurred after oral treatment with Alendronate ( Fosamax, Zometa )
or Risedronate ... - Xagena.it
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Osteonecrosis of the Jaw Information
Fosamax ( generic name - Alendronate
) is a type of drug known as bisphosphonates. Recently a link
has been found between bisphosphonates and a serious bone cancer disease called
osteonecrosis of the jaw ( ONJ ). This important discovery clearly
shows that Fosamax side effects may include
osteonecrosis of the jaw. The discovery, published in the Journal of Oral and
Maxillofacial Surgeons, prompted both the US, Food and Drug Administration (
FDA ) and Novartis, the manufacturer of bisphosphonates used in cancer
chemotherapy, to issue a warning to health care professionals on September 24,
2004. The warning letter contained information about jaw
cancer and bisphosphonates
and the risks of osteonecrosis in the jaw.
Bisphosphonates are commonly used in tablet form such
as Fosamax ( Alendronate Sodium ) to prevent and treat osteoporosis in
post-menopausal women. Stronger forms of bisphosphonates are commonly used in
the management of advanced cancers that have metastasized to the bone, where
the disease often causes bone pain and possibly even fractures. Several cancers
can involve or metastasize to the bone, including lung cancer, breast cancer,
prostate cancer, multiple myeloma,jaw cancer, and others. When bisphosphonates are given
in cancer chemotherapy, the drugs are given intravenously, and usually for
longer periods of time.
If you or a loved one have jaw
cancer and have been
injured as a result of Fosamax,Zometa, and Aredia side effects such as osteonecrosis of the jaw
contact today the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
.
.
Osteonecrosis of the Jaw
Jaw
Cancer
Osteonecrosis of the jaw ( ONJ ) is a condition in which the bone tissue in the
jaw fails to heal after minor trauma such as a tooth extraction, causing the
bone to be exposed. The exposure can eventually lead to infection and fracture
and may require long-term antibiotic therapy or surgery to remove the dying
bone tissue. Experts say that prevention and early treatment of individuals
using bisphosphonates such as Fosamax is extremely important in preserving the
jaw bone. Individuals using Fosomax or other bisphosphonates should attempt to
avoid tooth extractions and other major dental work while on the drugs.
Although most cases of osteonecrosis of the jaw related to Fosamax side effects
have occured after dental work several cases have been reported to occur
without any prior dental work. If you are currently taking Fosamax,Zometa, and
Aredia you may be
at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa,
and Aredia side
effects you may be entitled to compensation. For more information about your
legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
Osteonecrosis
What is Osteonecrosis?
Osteonecrosis literally means "dead
bone" It most often refers to a form of arthritis in which one of the bones
of a joint is affected by osteonecrosis, leading to arthritis in the joint.
Osteonecrosis is known by many other names, such as avascular necrosis or
ischemic necrosis. Osteonecrosis occurs because of a decrease in blood supply to
specific parts of bones. This decreased circulation causes cells in the bone and
bone marrow to begin to die. Eventually the dead section of bone weakens and
collapses.
What Causes Osteonecrosis?
Injuries such as fractures or
dislocations of certain bones, such as in the wrist or hip, can produce
osteonecrosis if the arteries supplying blood to these areas are damaged.
Blocked blood vessels, of any cause, will result in osteonecrosis. For example,
abnormal red blood cells (sickle cell anemia or thalassemia) or expanding
nitrogen bubbles (commercial deep-sea divers or tunnel workers who do not
decompress properly) can block blood vessels leading to osteonecrosis. Taking
corticosteroid medications such as prednisone, particularly in high doses, also
can reduce the bone blood flow by increasing the pressure with bone marrow and
blood flow.
Who Gets Osteonecrosis?
The following people are most at risk for developing osteonecrosis:
- those with certain fractures of the hip
- alcoholics
- those taking corticosteroids
- individuals with sickle cell anemia, lupus or
pancreatitis
Osteonecrosis most commonly occurs in large
joints such as the hips, knees, ankles and shoulders. People between the ages of
30 and 50 are most likely to develop osteonecrosis of the hip, with men
developing this condition slightly more frequently than women. Osteonecrosis of
the knee occurs most often in women between ages 50 and 60.
What Are the Symptoms?
Pain, both at rest and, in particular, with movement of the joint is the major
symptom of osteonecrosis. Other symptoms include limitation of motion, joint
stiffness and muscle spasms. Symptoms usually begin slowly. If the condition is
left untreated, progressive bone damage (bone collapse) may occur, which can be
associated with an increase in pain and loss of function of the joint. Surgery
may be required to correct this damage.
How is it Diagnosed?
Early diagnosis of osteonecrosis is important in order to prevent the affected
bone from collapsing. Information obtained from your medical history, along with
the results of a thorough physical examination, can help identify this
condition.
Diagnosis at this early stage is best made by magnetic
resonance imaging (MRI). MRI is a technique that produces cross-sectional
images of the body by exposure to magnetic energy sources (but without harmful
radiation). MRI is able to detect osteonecrosis before significant damage to the
bone has occurred and before changes on X-ray films are evident.
If the diagnosis is not made soon enough and the
condition is allowed to progress, inevitable damage to the bone will occur with
involvement of the corresponding joint. At this point, osteonecrosis produces
changes of the bone that can be detected on routine X-ray films of the joint.
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JWR had jaw cancer that involved his jaw bone
19 years ago. This is his story.
My story started late in 1983. I had noticed a
small lump about the size of a small pea on my
jaw bone. I was not concerned but my wife insisted
I see my GP.
My GP examined me and gave me a letter to take
to St Luke’s Hospital. A few days later I
got to see Mr Froggat, who along with another
doctor, wanted me in hospital for a biopsy. Later,
after the biopsy, I was sent to see Dr Ward at
Bradford Royal Infirmary who confirmed that the
lump was cancer. He arranged for me to have radiotherapy
at Cookridge Hospital which I attended for 20
days (excluding weekends). The staff were very
friendly and helpful, during and after the treatment.
Following the radiotherapy, I attended follow-up
clinics. After three I was declared free of this
jaw cancer. I was a very happy man!
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Because early detection vastly improves the likelihood of
cure, screening for jaw oral cancer should be an integral part
of medical and dental examinations. Osteonecrosis of the
jaw growths less
than ½ inch across usually can be cured. Unfortunately,
most cancerous growths are not diagnosed until they are larger
and have spread to the lymph nodes under the jaw and in the
neck. Because of delayed detection, 25% of oral jaw cancers are
fatal.
Although most cases of osteonecrosis of the jaw related to Fosamax side effects
have occured after dental work several cases have been reported to occur
without any prior dental work. If you are currently taking Fosamax,Zometa, and
Aredia you may be
at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa,
and Aredia side
effects you may be entitled to compensation. For more information about your
legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
IMF: Aredia/Zometa and osteonecrosis of the jaws A New Update ...
... finding was the apparent occurrence of jaw osteonecrosis in patients taking
bisphosphonates. ... How common is jaw osteonecrosis in myeloma patients? ...
www.myeloma.org/main.jsp?type=article& tab_id=1&menu_id=0&id=1259 - 50k |
eMJA: Bisphosphonates and osteonecrosis of the jaw (Medical
Journal of Australia) Bisphosphonates and osteonecrosis of the jaw.
www.mja.com.au/public/issues/ 182_08_180405/pur10144_fm.html - 30k - May 2, 2005 - |
ADRAC : bisphosphonates and osteonecrosis of the jaw ... Patients and their dentists should be advised of the risk of osteonecrosis of
the jaw so that any 'toothache' developing during treatment can be fully ...
www.xagena.it/news/medicinenews_net_news/ 05425f51eaeab268c26a5d42f2ccedaf.html - 15k - |
Although most cases of osteonecrosis of the jaw related to Fosamax side effects
have occured after dental work several cases have been reported to occur
without any prior dental work. If you are currently taking Fosamax,Zometa, and
Aredia you may be
at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa,
and Aredia side
effects you may be entitled to compensation. For more information about your
legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
|